Lung Cancer Archives

What is Lung cancer: Cancer which is found in the lungs is termed as lung cancer. Lungs are the softy organs located in the chest on both either side of the heart. Lungs are the essential organs useful in supplying oxygen in the blood to various parts of the body. Lung cancer is referred as the malignant tumor because it spreads through out the body, lung cancer cells usually travels through blood vessels into tissues and lymph nodes. So, during surgery process the lymph nodes are also removed to check for the cancer cells.

Lung cancer can spread to bone, gynecologic sytem, gastrointestinal system, heart and other organs. This kind of spreading nature is defined as metastatic lung cancer.

Occurrence of Lung cancer:

Lung cancer is a combination of several diseases with different types of causes, symptoms and treatments. It is of many types, in which abnormal growth of cells is common in all of them. Generally normal cells plays major role in defining cancer. All the organs and tissues in the body are made up by tiny body cells. These cells have a constant process of dying and replacing new cells. This is the general process carried by them, if there is any malfunction in their life cycle then there is a chance for the occurrence of lung cancer. Tumor occurs due to the formation of excess cells in the body. There are two types of Tumors one is benign tumor and the other is malignant tumor. Benign tumor is not cancerous but can cause damage to the adjacent organs if it grows continuously at a single site. Malignant tumor is cancerous. It spreads through out the body and damages the entire body organs.

Causes of Lung cancer: Many of the researchers doesn’t know the exact cause for the occurrence of Lung cancer, but the risk factors for the occurrence of Lung cancer is identified. Here is the list of risk factors.

Risk factors of Lung cancer:

Smoking: This activity is the major risk factor in causing Lung cancer. Smoking leads to lung cancer and also causes several side effects like digestion problems, burning sensation, headache and site blindness. So avoid smoking to prevent Lung cancer from occurrence.

Second hand of smoking: This activity is also the major risk factor in causing cancer. Passive smoking also leads to lung cancer but at comparatively slow rate.

Age: Generally aged people will be suffering from lung cancer due to decrease in immune power system and increase in pollution causing factors .if the age is above 50 years, there will be more chances of getting lung cancer due to the increase in risk factors.

Radon gas: Radon gas is a mixture of several chemical agents. it is a decay compound of uranium which increases risk factors for lung cancer. Nearly 12 percent of lung cancer is caused due to radon gas.

Asbestos fiber: Exposure to asbestos fiber for longer duration will increase the risk factors for lung cancer.

Air pollution: Air pollution is one of the leading factors for increasing the causes of lung cancer. Pollution from vehicles, factories and power plants can raise the risk factor for up to 2 percent.

Lung diseases: Due to presence of lung disease like chronic obstructive pulmonary disease, the risk factor rate is increased by 1 to 2 percent in a year.

Family pedigree: Genetic susceptibility also plays major role in increasing the risk factors for lung cancer.

Symptoms and signs of Lung cancer: Lung cancer is termed as a silent disease because it doesn’t show any symptoms in the early stage of its occurrence.

• Jaundice
• Diarrhea
• Muscle spasms
• Nausea and vomiting
• Headache
• Digestion problem
• Urination infections
• Weight loss
• Tiredness
• Pneumonia
• Hoarseness
• Dysphaqia
• Stroke
• Loss of sensations in the body parts
• Blood in sputum
• Persistent bronchitis
• Breathing difficulties

These are the possible symptoms of Lung cancer. If you find any of these symptoms please go for screening test to prevent this slow cancer disease.

Effects of lung cancer:

Sleep disorder: Severe illness, stress, emotional pain and usage of drugs are the driving factors for causing sleep disorder. People suffering with this cancer disease will generally face this disorder .

Nausea and vomiting: Body hormone changes, pains, body inflammation, poor blood flow and anxiety are the causing factors of nausea and vomiting.

Fatigue: Due to the excess treatment process of cancer ,body faces severe exhaustion or tiredness.

Delirium: This side effect occurs during the last period of life .Delirium is nothing but the malfunction of the brain due to severe attack of cancer cells in the body.

Constipation: Constipation occurs during the early stage of the cancer. Constipation means slow movement of body waste through the body. Due to constipation the body faces illness.

Treatment methods for Lung cancer:

Curing of this lung cancer should be done in the early stages before it spreads through out the body or else it can’t be cured. Lung cancer can be treated with Surgery, Radiotherapy ,Chemotherapy and Biotherapy.

Surgery: Surgery is carried to remove the lung cancer. Surgery can be carried in the early stages of the tumor occurrence. Surgery will be taken place only if the tumor is located in only one part of the body. During the surgery process the damaged lymph nodes are also removed along with the tumor. During surgery the entire lung or part of it will be removed if necessary. During some cases, the major portion of the lung will be removed along with other tissues for avoiding spreading of the disease. About 20 percent of lung cancer cases will be cured by surgeries but removal is not a cure because the tumor cells spreads through out the lungs. So surgery alone can’t cure lung cancer, we require chemotherapy and radiation therapy for complete curingof this lung cancer.

Radiation therapy: This treatment is based on the extent of the disease. Radiotherapy is a useful process in removing lung cancer cells by using high intensity x-rays. These high energy x-rays are aimed at the lung tumor to destroy the cancer cells .This process also causes damage to the normal cells for its side effects. There are two types of radiation therapy.

  • External Radiation Therapy: External radiation therapy process is carried out from outside the body. The powerful x-ray beams are aimed at the effected area from outside the body and destroys the cancer causing cells permanently without re-occurrence.
  • Internal Radiation Therapy: Internal radiation therapy process is carried out from inside the body. The powerful x-ray beams are aimed at the effected part by making small incisions to destroy the cancer causing cells permanently without re-occurrence. This process gives better results than external radiation.

Chemotherapy: Chemotherapy drugs are called as anti-cancer drugs used to destroy lung cancer cells .There are many types of chemotherapy drugs available in the market for the treatment of cancer. This treatment process is carried by either pills or through intravascular injections. The anti-cancer drug enters into the bloodstream and travels towards the damaged tissues of lungs and destroys the cancer cells.

Chemotherapeutic drugs attacks the cancer cells by stopping their unusual growth. The nature of the cancer cells were brought to the normal condition by controlling the divisibility of the cells. These drugs are carried in the bloodstream to kill all the cancer cells within short period of time. Chemotherapy is useful in killing cancer cells, avoids spreading of cancer cells to various parts of the body, stops multiple divisions of lung cancer cells and avoids replacing of non-cancerous cell into cancerous cells.

Biotherapy: Body possesses weak immune system due to the effect of lung cancer cells. So, due to weak immune system in the body, there are chances for the development of lung cancer cells in the body. So this Biotherapy treatment process is useful in rebuilding strong immune system in the body. Biotherapy is also called as immunotherapy or biological response modifier therapy. This treatment process is really useful in repairing, enhancing and stimulating the weak immune system of the body. This process can be carried along with surgery, chemotherapy and radiotherapy.

Targeted therapy: Targeted therapy drugs are very useful in blocking the growth of cancer cells. People facing with chronic myeloid leukemia and acute lymphoblastic leukemia can use this targeted therapy drugs for better results.

Treatment of recurrence: Surgery is the treatment method for recurrence of lung cancer. This recurrence treatment is very useful in curing the lung cancer. It stops the re-occurrence of this disease after having treatments.

Photodynamic therapy: This therapy is a new method for treating lung cancer by injecting photosynthesizing agent directly into the bloodstream by using intravascular injection. This agent spreads through the cancer cells and itself deposits with the cancer cells and after that doctor performs some surgery to apply a certain wavelength of light through hand held wand. This instrument targets the light directly on the photosynthesizing agent and burns the cancer causing cells. This method is useful in advanced stage of lung cancer.

Lung cancer is termed as a serious cancer disease. It is mainly caused due to smoking of tobacco. This disease can be cured only in the early stage of its occurrence. Lung cancer causes any other cancer related diseases in the body due to its metastatic characteristics. Lung cancer symptoms cannot be identified in the early stages. Later on its improvement we can find some symptoms which are listed above. Lung cancer is the most leading disease around the world.

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Author shares information on causes, symptoms, effects, risk factors, preventions, treatments, prognosis of diseases like cancer, diabetes, heart attack, obesity and also shares information on Men’s health, women’s health, sexual health, mental health, health and fitness, pregnancy, Blood disorders, Muscles, bones and joints, Health issues, and Weight loss.

Article Source: ArticlesBase.comCauses ,effects symptoms and treatments of lung cancer

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For answers to your questions and facts about lung cancer, read on for details about causes of the disease, how it’s treated and how it can be prevented.

Is there more than one type of lung cancer?

There are two types of lung cancer – non-small cell and small cell lung cancer. The two types are distinguishable because of how the cancer cells expand, grow and spread throughout the body.

There are three types of non-small cell lung cancer (the most common form of lung cancer). They are adenocarcinoma, squamus cell carcinoma, and large-cell carcinoma. Though rarer, small cell lung cancer occurs in approximately a quarter of all people diagnosed with lung cancer.

Can I prevent lung cancer?

There are three ways to prevent lung cancer – quit smoking, avoid second-hand smoke and stay away from air-borne carcinogens at work. If you’re concerned about your risk of developing lung cancer, avoiding tobacco smoke is typically your best defense.

What are the major causes of lung cancer?

The primary cause of lung cancer in most cases is smoking tobacco products. Of all the facts about lung cancer, this is the most critical and apparent. The carcinogens in tobacco smoke will damage cells. Other causes include exposure to carcinogens like asbestos or radon. Genetics may also play a role in the prevalence of the disease.

How do doctors detect lung cancer?

The early stages of lung cancer typically don’t exhibit any symptoms. The only sure-fire way to detect the disease is with a chest X-ray.

For a confident diagnosis, a biopsy is required. When a doctor performs a biopsy, he or she removes a small amount of tissue from the lung to test it for cancerous cells.

Does lung cancer have any symptoms?

Most lung cancer symptoms don’t appear until after the disease has reached the later stages. That said, the symptoms include constant coughing or wheezing, loss of appetite, chest pains, upper abdomen pains, bronchitis or pneumonia, blood being coughed up, general fatigue, a persistent hoarse voice and a dry, sore throat.

Can lung cancer be treated and how?

Lung cancer can be treated, but the treatments will depend on how far advanced the disease has progressed, the patient’s strength and the type of lung cancer. Lung cancer is typically treated with one of – or a combination of – chemotherapy, radiation therapy and surgery.

Is mesothelioma a type of lung cancer?

Mesothelioma is a rare form of lung cancer that is typically caused by asbestos exposure. The disease attacks the delicate skin lining of the lungs, and tumors form.

Are men or women more at risk?

Female smokers are twice as likely to develop lung cancer than male smokers.

I’m older and a smoker, will quitting really help me?

Yes, quitting at any age can help prevent lung cancer. The risk of developing lung cancer is reduced dramatically each year a person smokes – whether that person is 20 or 70. Of all the facts about lung cancer, probably the most saddening is that the majority of cases are preventable.

About the Author:For helpful information on various cancers, please visit cancerinfotips.com, a popular site providing symptom and treatment insights, such as a kidney cancer symptoms, immune system supplements, and many more!

Article Source: ArticlesBase.comInformation and Often Submitted Inquiries About Lung Cancer

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Cisplatin these drug are mostly used in the initial lung cancer treatment. Efficiency of this drug in combination with other drugs is being explored by a few of scientist these past few years. In year 2008, United States Food and Drug Administration (FDA) approved the combination of cisplatin and alimta as a first line lung cancer treatment. In combination with other drug that against of advance non small cell lung cancer especially maligant pleural mesothelioma.

In year 2007, based on Journal of National Cancer Institute has stated that cisplatin has more effective response rate than carboplatin in the advance non small cell lung cancer treatment. Carboplatin is a form lung cancer chemotherapy agent and used for treatment many types of cancer especially ovarian and non small cell lung cancer. Another similar finding from Science Daily, in year 2008. Andrea Ardizzoni, M.D., of University Hospital in Parma, Italy, he and his colleague conducted a review of nine randomized trials comparing the survival of 2,968 non small cell lung cancer patients who received either cisplatin or carboplatin, finding showed that patients who under treatment with cisplatin lived longer than those treated with carboplatin.

Cisplatin chemotherapy is usually given as a course of several sessions (or cycles) of treatment over a few months. The length of your treatment and the number of cycles you have will depend on the type of cancer for which you are being treated. Cisplatin is sometimes given alongside other chemotherapy drugs as part of a combination regimen. Your nurse or doctor will discuss your treatment plan with you.

These results suggest that cisplatin produces slightly better response rates than carboplatin and may also improve survival in some patients.

About the Author:Author Tony Koay, Malaysia. More info please visit www.earthrises.net
Article Source: ArticlesBase.com – Cisplatin: Product review for lung cancer chemotherapy

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In year 2007, United States was already approved Avastin as a first line lung cancer treatment for patients with advance non small cell lung cancer in combination with platinum based echemotherapy.

Avastin is indicated for the first-line treatment of unresectable, locally advanced, recurrent or metastatic non–squamous non–small cell lung cancer in combination with carboplatin and paclitaxel.

Based on the drug maker Roche said that avastin is the only first-line treatment to demonstrate improved survival benefits beyond one year in patients with advanced lung cancer and is the first treatment that inhibits angiogenesis, which is the growth of a network of blood vessels that supply nutrients and oxygen to cancerous tissues.

Avastin targets a naturally occurring protein called VEGF (Vascular Endothelial Growth Factor), a key mediator of angiogenesis, thus choking off the blood supply that is essential for the growth of the tumor and its spread throughout the body.

According to Land Mark US study, avastin is the first medicine proven to help previously untreated patients suffering from the most common form of lung cancer to live longer than a year. There result showed that the duration of survival lung cancer patients who took in the Avastin with carboplatin chemotherapy group was 12.3 months compared to 10.3 months in the group treated with chemotherapy alone. Which extended lung cancer patients with 2 more months.

Avastin is the first and only anti-angiogenic agent to have demonstrated improved overall and/or progression-free survival in four major tumour types, namely: colorectal cancer, non-small cell lung cancer, breast cancer and renal cell carcinoma.

In year 2006, American Society of Clinical Oncology announced that avastin combination with erlotinib was delivered with promising preliminary results in the treatment of refractory non-small cell lung cancer in data. Based on the study, the 17.9% response rate with the avastin-erlotinib combination was better than the 12.5% rate seen in patients treated with avastin and chemotherapy and the 12.2% rate seen in those treated with chemotherapy alone.

Avastin inhibits the growth of blood vessels, which is part of the body’s normal healing and maintenance. The body grows new blood vessels in wound healing, and as collateral circulation around blocked or atherosclerotic blood vessels. One concern is that avastin will interfere with these normal processes, and worsen conditions like coronary artery disease or peripheral artery disease.

The main side effects are hypertension and heightened risk of bleeding. Bowel perforation has been reported. In advanced lung cancer, less than half of patients qualify for treatment. Brain capillary leak syndrome, nasal septum perforation, and renal thrombotic microangiopathy have been reported.

About the Author:Author Tony koay, Malaysia more info please visit www.earthrises.net
Article Source: ArticlesBase.com – Combo avastin with other medicine extended lung cancer patient

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Researchers from Ohio State University Comprehensive Cancer Center and at the National Cancer Institute has found out a protein that appears to play a essential role in lung cancer in non-smokers. It opens up the possibilities for new lung cancer treatment for this deadly malignancy.

They hope that the new finding (lung cancer treatment) could further improved chemotherapy for lung cancer in both never-smokers and smokers, including those with tumours resistant to targeted drugs such as gefitinib and erlotinib.

The findings, published online recently in the Proceedings of the National Academy of Sciences, They hope that the new finding could further improved chemotherapy for lung cancer in both non smokers and smokers, including those with tumours resistant to targeted drugs such as gefitinib. American and Japanese scientist involved in this new study believe that the miR-21 protein is not only a marker of disease, like PSA levels are in prostate cancer screenings, but an actual contributor to the cancer process

During examining lung tumors from patient who had never smoked and the research found high levels of a molecule called miR-21. The levels were even higher in tumors that had mutations in a gene called EGFR, a common feature of lung cancer in never-smokers.

“Several important lung cancer drugs target EGFR mutations, but these agents are ineffective in about 30 percent of cases in which the mutation is present,” says co-principal investigator Dr. Carlo M. Croce, professor of molecular virology, immunology and medical genetics at the Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute. “Our study suggests that developing agents to inhibit miR-21 might improve these anti-EGFR therapies.”

Core and his scientist’s team examined lung cancer sample from 28 cases of lung tumor tissue and all of them are non smoker who had adnocarcinoma. Nearby healthy lung tissue from non smokers for changes in micro RNA, molecules that help cells regulate the kind and amount of proteins they make.

MiR-21 is also elevated in tobacco-related adenocarcinoma, but to a lesser extent. Earlier research also showed that elevated levels of miR-21 and other micro RNAs were markers for poor survival in smoking-related lung cancer. According to researcher Harris.

The researchers took cells that had a mutated EGFR gene and treated them with an anti-EGFR agent, it related two therapies for specific lung cancers follow the line of scientific though- gefitinib and erlotinib. As expected, the drugs were most effective killing the cancer cells. But when they blocked both EGFR and MIR-21, the proportion of cells killed rose still more

“It’s a long road from ‘bench to bedside,’” Lichtenfeld said of the findings “But clearly this study offers the suggestion that there can be an effective lung cancer treatment for nonsmokers whose adenocarcinoma shows miR-21 elevation

Source: Curtis Harris, M.D., U.S. National Cancer Institute, Bethesda, Darrell E. Ward Ohio State University Medical Center, the Intramural Research Program of the National Institutes of Health, National Cancer Institute and Center for Cancer Research

About the Author:Author Name: Tony Koay
Malaysia: Malaysia Age 29 more info please visit: www.earthrises.net

Article Source: ArticlesBase.com – Molecule play key role in non smoker’s lung cancer

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